( CNN) Lots of Cabinet officials — and I mean Plenties — have either resigned or been fired by President Donald Trump in his first 20 months in office. But no one has discontinued in quite the same way as Defense Secretary James Mattis did Thursday night.

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“One core belief I have always held is that our strength as a nation is inextricably linked to the strength of our unique and comprehensive system of confederations and partnerships. While the US remains the indispensable nation in the free world, we cannot protect our interests or serve that role effectively without maintaining strong alliances and showing respect to those allies.”

That objective Thursday — with the letter that seemed to be months of pent-up frustrations by Mattis loosed, in written form, on Trump.

With Tillerson gone and Mattis and Kelly on their way out, the prevailing sentiment among establishment Republicans in Washington was one of thinly veiled panic.