Washington( CNN) The death of Uzbekistan President Islam Karimov could pose serious challenges for the US in areas such as counterterrorism and could become another flash point in the contentious US-Russia relationship.

Since 9/11, Uzbekistan has been at times critical to US foreign policy objectives in Central and South Asia, including in Afghanistan and in efforts to curb Russian influence in the region. Here's a look at some of the key styles Karimov's death could affect the US.